Investigation on the Expectorant Effect of Extracts from Primula veris L.

BACKGROUND: At present, coughing can be regulated by medications such as dextromethorphan and codeine, which are associated with side effects, including drug drowsiness or dependency. Thus, there is an increasing demand for drugs that promote expectorant activities fewer adverse effects. The root of Primula veris L. (Primulaceae) herbal medicine has been used thousands years in folk medicine. AIM: present study aims to create in-depth pharmacological the activity P. new different directions appropriate promising. MATERIALS AND METHODS: effect thick extracts plant was studied on influence motor ciliated epithelium secretory function bronchi. ethanol leaves rhizomes roots from were evaluated using classical animal models. assay performed phenol red secretion mouse trachea. After gastric administration test mice, 2.5% solution injected intraperitoneally. trachea dissected optical density tracheal measured. RESULTS: results studies showed a extract primrose high ability secrete sputum, almost not inferior Hedelix drops comparator (ivy extract) – 126.6% 146.4%, respectively. Extract characterized less pronounced activity, which, at dose 200 mg/kg, 74.5%. CONCLUSION: provide evidence triterpene saponins may main active ingredients responsible its bioactivities.